4-(N-Boc-amino)piperidine → HCID 68816915, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-chloro-2-{2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidin-1-yl}-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidine (Example 17) (150 mg, 0.35 mmol) and 4-(N-tert-butoxycarbonylamino)piperidine (700 mg, 3.5 mmol) were added to dioxane (4 ml) and heated in a sealed vessel under microwave irradiation at 150° C. for 60 minutes. The crude reaction mixture was purified by reverse phase HPLC using a C18 column eluting with water/acetonitrile/TFA (95:5:0.2 decreasing in polarity to 0:100:0.2). The product containing fractions were passed down an SCX-2 column eluting with methanol and then releasing the product with 2N methanolic ammonia. The solvent was removed by evaporation to give the title compound (134 mg, 64%) as a white solid.

Provenance & Evidence