Trifluoroacetic acid → HCID 68813644, compound

Participants

Reaction Steps

6-(4-(N-tert-Butoxycarbonylamino)piperidin-1-yl)-2-{2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidin-1-yl}-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidine (Example 124) (120 mg, 0.20 mmol) was stirred in DCM (10 ml) and trifluoroacetic acid (2 ml) was added and the mixture stirred at room temperature for 3 hours. The mixture was concentrated by evaporation and the residue dissolved in methanol (10 ml) and passed down a 20 g SCX-2 ion exchange column, eluting with methanol to elute impurities and then 2M methanolic ammonia to elute the product. The solvent was removed by evaporation to give the title compound (79 mg, 81%) as a cream powder.

Provenance & Evidence