Benzaldehyde → HCID 178482600, compound

Participants

Reaction Steps

Freshly distilled benzaldehyde (373 mg, 3.5 mmol) was added to a solution of 5-aminomethyl-3-(pyrid-2-yl)isoxazole (Method 70 of WO 03/048133) (0.614 mg, 3.5 mmol) in dry DCM (18 ml). 4 Å molecular sieve (1.75 g) was then added and the mixture stirred gently under nitrogen for 20 hours. The molecular sieve was removed by filtration and the filtrate evaporated. The residue was dissolved in toluene and the solution concentrated by evaporation. The product crystallised and was collected by filtration to give the title compound (900 mg, 97%).

Provenance & Evidence