HCID 68813464, compound → HCID 68813851, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(3-cyclopropylisoxazol-5-yl)pyrrolidine (Method 14) (2.05 g, 11.5 mmol) and formamidinesulphonic acid (1.425 g, 11.5 mmol) in dry methanol (30 ml) was heated at 60° C. for 18 hours. The solvent was removed by evaporation and the residue dissolved in water. The aqueous solution was washed with water and then the water removed by evaporation. The residue was triturated with ether/DCM, the solid product was collected and dried under vacuum at 50° C. for 18 hours to give the title compound monosulphate salt (1.839 mg, 41%); m/z 221 [MH]+.

Provenance & Evidence