Water → 2,6-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

HRID 2105229Notes

Reaction equation

HRID 2105229 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH2:10][C:11]1[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=1.C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:10][C:11]2[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=2)[CH:5]=[C:6]([Cl:8])[N:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 773782,4,6-TrichloropyrimidineHCID 931461H-Pyrazol-3-amine, 5-methyl-

Product 1

HCID 575560032,6-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amineYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2,4,6-trichloropyrimidine (1.0 g, 5.4 mmol), 3-amino-5-methyl-1H-pyrazole (0.53 g, 5.4 mmol), and sodium carbonate (0.57 g, 5.4 mmol) in ethanol (25 ml) was stirred at ambient temperature for 18 hours. Water was added and the resulting precipitate was collected by filtration washed with water and a small amount of methanol, and dried to give the title compound (1.15 g, 88%) as a colourless crystalline solid.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water
  3. dry with materiala small amount of methanol, and dried

Sources & evidence

ORD record
ord-22d349c2bb3947168e062d1ea2a978cc
Source dataset
uspto-grants-2009_08
Patent number
US07579349B2

Reaction notes

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