Acetyl chloride → HCID 68814580, compound

Participants

Reaction Steps

Acetyl chloride (0.28 ml, 3.94 mmol) was added to a mixture of 6-hydrazide-2-{2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidin-1-yl}-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidine (Example 77) (800 mg, 1.79 mmol) and triethylamine (0.6 ml, 4.13 mmol) in anhydrous THF (20 ml) at 0° C. The reaction was allowed to warm to ambient temperature and stirred for a further 1 hour. The volatiles were removed by evaporation and the residue triturated with water and collected by filtration to give the title compound (911 mg, 96%).

Provenance & Evidence