Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 22335511 | HCID 22335511 | — |
| Product | HCID 9816253 | HCID 9816253 | 86.6% |
Reaction Steps
A mixture of 4-[1-(1H-imidazol-1-yl)-2-methylpropyl]benzenamine (0.0185 mol) in formic acid (20 ml) was stirred and heated at 120° C. for 15 minutes. The mixture was poured into water, basified with NaOH 3N and extracted with EtOAc. The organic layer was dried, filtered off and the solvent evaporated, yielding 3.9 g (86.6%) of (±)—N-[4-[1-(1H-imidazol-1-yl)-2-methylpropyl]phenyl]formamide (compound 177).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07579352B2 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-ec3454f7affd4f7db4e54ae3a9d75a16 |
|---|
| Source note | uspto-grants-2009_08 |
|---|
