反应详情

5-bromo-2-iodopyrimidine (250 mg), 4-trifluoromethylphenylboronic acid (167 mg), bis(triphenylphosphine)palladium(II) chloride (22 mg) and Na2CO3 (2.1 ml, 1M in H2O) in argon saturated acetonitrile (2.1 ml) was heated under microwave conditions (150° C., 10 minutes). The conversion was monitored and analyzed by HPLC. The crude reaction mixture was concentrated to dryness, then diluted with CH2Cl2, washed with water (3×10 ml), dried over Na2SO4, concentrated under vacuum and purified by chromatography column using CH2Cl2-hexane 1:10 as eluent to give 160 mg of the desired product as a white solid.

1. customThe crude reaction mixture
2. concentrationwas concentrated to dryness
3. additiondiluted with CH2Cl2
4. washwashed with water (3×10 ml)
5. dry with materialdried over Na2SO4
6. concentrationconcentrated under vacuum
7. custompurified by chromatography column