2-Chloro-6-methylaniline → HCID 57808606, compound

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Reaction Steps

Using the procedure of Example 1, 2-chloro-6-methyl-phenylamine Compound 48a was used in place of 3-chloro-4-fluoro-phenylamine Compound 1e to prepare 4-chloro-6-(2-chloro-6-methyl-phenylamino)-pyrimidine-5-carbonitrile Compound 48b. Using the procedure of Example 3, Compound 48b was used in place of 4-chloro-6-(2-chloro-4-fluoro-phenylamino)-pyrimidine-5-carbonitrile Compound 3b to prepare 5-(2-chloro-6-methyl-phenyl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,6,8-tetraaza-acenaphthylene-2-carboxylic acid Compound 4&. MS 361, 363 (MH+). Using the procedure of Example 1, Compound 48c was used in place of Compound 1 and 4-morpholin-4-ylmethyl-phenylamine Compound 3e was used in place of 4-piperidin-1-ylmethyl-phenylamine Compound 1k to prepare Compound 146. MS 535, 537 (MH+).

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