4-Nitrophenol → 4-(1-Methylpiperidin-3-ylmethoxy)-phenylamine

Participants

Reaction Steps

Using the procedure of Example 56, 4-nitro-phenol Compound 104a was used in place of Compound 36a and 3-chloromethyl-1-methyl-piperidine Compound 104b was used in place of Compound 56a and carried forward to provide 4-(1-methyl-piperidin-3-ylmethoxy)-phenylamine Compound 104d. MS 221 (MH+). Using the procedure of Example 1, 5-(2,4-dichloro-phenyl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,6,8-tetraaza-acenaphthylene-2-carboxylic acid Compound 43c was used in place of Compound 1 and Compound 104d was used in place of 4-piperidin-1-ylmethyl-phenylamine Compound 1k to give Compound 32. MS 583, 585, 587 (MH+).

Provenance & Evidence