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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2105350Generated: October 30, 2026

Ethyl 5-(phenylmethoxy)-1H-indole-2-carboxylate → HCID 68466524, compound

https://huagongshe.com/reaction/2105350

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 5-(phenylmethoxy)-1H-indole-2-carboxylateHCID 95721—
ReactantPotassium tert-butoxideHCID 23665647—
Reactant(4R)-2,2-Dioxido-4-methyl-1,2,3-oxathiazolidine,N-BOC protectedHCID 46172873—
ProductHCID 68466524HCID 68466524100%

Reaction Steps

The title compound was synthesized in analogy to example 1, intermediate b), from ethyl 5-benzyloxyindole-2-carboxylate (commercially available), (R)-4-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester (prepared according to WO02/010169) and potassium tert-butoxide, to give the desired compound as a light yellow solid (>100%). The so-obtained product was used in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07579351B2
Source datasetuspto-grants-2009_08
ORD IDord-568f7ef53dd54e5f87cb98bb434c5c35
Source noteuspto-grants-2009_08