HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → (S)-8-(1-Isopropyl-piperidin-4-yloxy)-2-(2-methoxy-ethyl)-3-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | HCID 16679616 | HCID 16679616 | — |
| Product | (S)-8-(1-Isopropyl-piperidin-4-yloxy)-2-(2-methoxy-ethyl)-3-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one | HCID 16678317 | 30% |
Reaction Steps
The title compound was synthesized in analogy to example 17, from (S)-8-(1-isopropyl-piperidin-4-yloxy)-3-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 13), 2-bromoethyl methyl ether and sodium hydride, to give the desired product as a colorless oil (30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579351B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-775990b654de4fbb9191880fa5f2ae86 |
| Source note | uspto-grants-2009_08 |