Sodium hydride → 2-[8-(1-Isopropyl-piperidin-4-yloxy)-1-oxo-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl]-N-methyl-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Sodium hydride	HCID 24758	—
Reactant	2-chloro-N-methylacetamide	HCID 66773	—
Reactant	8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	HCID 16679518	—
Product	2-[8-(1-Isopropyl-piperidin-4-yloxy)-1-oxo-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl]-N-methyl-acetamide	HCID 16678321	—

Reaction Steps

The title compound was synthesized in analogy to example 17, from 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 1), sodium hydride and 2-chloro-N-methylacetamide, to give the desired product in a yield of 68%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07579351B2
Source dataset	uspto-grants-2009_08
ORD ID	ord-41d21d1a312e4d44874930330ba543f8
Source note	uspto-grants-2009_08