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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2105381Generated: November 1, 2026

Sodium hydride → HCID 16678419, compound

https://huagongshe.com/reaction/2105381

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant1-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 123057—
Reactant8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-oneHCID 16679518—
ProductHCID 16678419HCID 1667841993%

Reaction Steps

The title compound was synthesized in analogy to example 17, from 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 1), sodium hydride and 2-(trifluoromethyl)benzyl bromide, to give the desired product as a light yellow foam (93%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07579351B2
Source datasetuspto-grants-2009_08
ORD IDord-59b3a2e51b2643ef893dfa4873ead50c
Source noteuspto-grants-2009_08