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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2105392Generated: November 2, 2026

3-(Chloromethyl)pyridine hydrochloride → HCID 16678619, compound

https://huagongshe.com/reaction/2105392

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Chloromethyl)pyridine hydrochlorideHCID 23394—
ReactantSodium hydrideHCID 24758—
Reactant8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-oneHCID 16679518—
ProductHCID 16678619HCID 1667861978%

Reaction Steps

The title compound was synthesized in analogy to example 17, from 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 1), sodium hydride (2.4 equivalents) and 3-(chloromethyl)pyridine hydrochloride, to give the desired product as a white solid (78%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07579351B2
Source datasetuspto-grants-2009_08
ORD IDord-6630e84a1ae142ff800e5990af85c077
Source noteuspto-grants-2009_08