HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 16678832, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Isoxazole, 4-(chloromethyl)-3,5-dimethyl- | HCID 88246 | — |
| Reactant | (R)-8-(1-isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679612 | — |
| Product | HCID 16678832 | HCID 16678832 | 66% |
Reaction Steps
The title compound was synthesized in analogy to example 17, from (R)-8-(1-isopropyl-piperidin-4-yloxy)-4-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 8), sodium hydride and 4-(chloromethyl)-3,5-dimethylisoxazole, to give the desired product as a white solid (66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579351B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-1309aec2d0a649da98a6569063b19dc3 |
| Source note | uspto-grants-2009_08 |