Bis(4-methoxybenzyl)amine → HCID 86625944, compound

Participants

Reaction Steps

In step (2) of Reaction Scheme IV, an N-(2-chloro-3-nitropyridin-4-yl)hydroxylamine of Formula XXXVIII is reacted with bis-(4-methoxybenzyl)amine to provide an N-{2-[bis-(4-methoxybenzyl)amino]-3-nitropyridin-4-yl}hydroxylamine of Formula XXXIX. The reaction can be carried out by adding the bis-(4-methoxybenzyl)amine to a solution of a compound of Formula XXXVIII in a suitable solvent such as toluene in the presence of a base such as triethylamine. The reaction can be carried out at an elevated temperature (about 90° C.).

Provenance & Evidence