HCID 178507989, compound → HCID 178514217, compound

HRID 2105456Notes

Reaction equation

HRID 2105456 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[OH:12])=[N:9][CH:8]=[CH:7][CH:6]=2.[NH2:13][C:14]1[CH:15]=[N:16][C:17]2[C:22]([C:23]=1[OH:24])=[CH:21][CH:20]=[CH:19][CH:18]=2>>[OH:12][C:11]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][N:9]=2)[N:4]=[CH:3][C:2]=1[NH-:1].[OH:24][C:23]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][C:14]=1[NH-:13]

Participants

4

Reactant 2

HCID 178507989HCID 178507989, compoundHCID 178508000HCID 178508000, compound

Product 2

HCID 178514217HCID 178514217, compoundHCID 178514218HCID 178514218, compound

Procedure

In step (1) of Reaction Scheme VI, a 3-amino[1,5]naphthyridin-4-ol or 3-aminoquinolin-4-ol of Formula XXX is reacted with an acyl halide of Formula R2C(O)Cl or R2C(O)Br to provide an N-(4-hydroxy[1,5]naphthyridin-3-yl)amide or N-(4-hydroxyquinolin-3-yl)amide of Formula LVIII. The reaction can be carried out using the method described in step (2) of Reaction Scheme I.

Workup

  1. customIn step (1) of Reaction Scheme VI

Sources & evidence

ORD record
ord-5b23e241ba954f4b8f5756fd01f00e60
Source dataset
uspto-grants-2009_08
Patent number
US07579359B2

Reaction notes

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