Hydroxyamine hydrochloride → 1h-Imidazo[4,5-c][1,5]naphthyridine

Participants

Reaction Steps

In step (3) of Reaction Scheme VI, a [1,5]naphthyridin-3-yl trifluoromethanesulfonate or quinolin-3-yl trifluoromethanesulfonate of Formula LIX is reacted with a hydroxylamine hydrochloride of Formula R1ONH2.HCl and cyclized to provide a 1H-imidazo[4,5-c][1,5]naphthyridine or a 1H-imidazo[4,5-c]quinoline of Formula XXXIII. The reaction can be carried out using the method described in step (3) of Reaction Scheme I.

Provenance & Evidence