Hydroxylamine → 1h-Imidazo[4,5-c][1,5]naphthyridine

Participants

Reaction Steps

In step (1) of Reaction Scheme VII, an N-(4-chloro[1,5]naphthyridin-3-yl)amide or N-(4-chloroquinolin-3-yl)amide of Formula XXXII is reacted with a hydroxylamine of the Formula Boc-CH2—X—CH2—ONH2 and cyclized to provide a 1H-imidazo[4,5-c][1,5]naphthyridine or a 1H-imidazo[4,5-c]quinoline of Formula LX. The reaction can be carried out using the method described in step (3) of Reaction Scheme I. Hydroxylamines of the Formula Boc-CH2—X—CH2—ONH2 can be prepared by conventional methods.

Provenance & Evidence