反应详情

O-isopropylhydroxylamine hydrochloride (2.14 g, 1.7 eq) was added to a solution of N-(4-chloroquinolin-3-yl)acetamide (2.51 g, 1.0 eq) in ethanol (75 mL). The reaction mixture was heated at reflux for 2 hours and then concentrated under reduced pressure. The residue was partitioned between dichloromethane and aqueous saturated sodium bicarbonate. The organic layer was separated and concentrated under reduced pressure to provide 2.60 g of 1-isopropoxy-2-methyl-1H-imidazo[4,5-c]quinoline.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 2 hours
3. concentrationconcentrated under reduced pressure
4. customThe residue was partitioned between dichloromethane and aqueous saturated sodium bicarbonate
5. customThe organic layer was separated
6. concentrationconcentrated under reduced pressure