HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-tert-butylhydroxylamine hydrochloride → 1-tert-butoxy-1H-imidazo[4,5-c]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-tert-butylhydroxylamine hydrochloride | HCID 2777906 | — |
| Reactant | N-(4-chloroquinolin-3-yl)formamide | HCID 86227468 | — |
| Product | 1-tert-butoxy-1H-imidazo[4,5-c]quinoline | HCID 67506080 | 70.5% |
Reaction Steps
4-Chloroquinolin-3-ylformamide (4.1 g, 0.020 mol) was treated with O-(tert-butyl)hydroxylamine hydrochloride (2.8 g, 22 mmol) according to the method of Part B of Example 20 to provide 3.4 g of 1-tert-butoxy-1H-imidazo[4,5-c]quinoline, which was used without chromatographic purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579359B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-ebcb214f86f64e73b98249c24301ca6e |
| Source note | uspto-grants-2009_08 |