反应详情

The solution of 2-chloro-6-(4-methylphenyl)-5-phenylnicotinonitrile (2-4; 0.066 g, 0.217 mmol), NBS (0.046 g, 0.26 mmol) and benzoylperoxide (0.010 g, 0.043 mmol) in CDCl3 (2 mL) was heated to reflux overnight. The mixture was concentrated to give 6-[4-(bromomethyl)phenyl]-2-chloro-5-phenylnicotinonitrile (2-5) and used without further purification. LRMS m/z (M+H) Calcd: 383.7, found: 383.1.

1. temperatureto reflux overnight
2. concentrationThe mixture was concentrated