Ethyl isocyanate → HCID 11238478, compound

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The mixture of 2-amino-6-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-5-phenylnicotinonitrile (6-3; 0.025 g, 0.05 mmol) and ethylisocyanate (0.007 mg, 0.100mmol) in THF (1 mL) was heated to 100 C for 0.5 h and concentrated. The residue was purified by silica gel chromatography (3-6% MeOH in CH2Cl2) to give the title compound (7-1). LRMS m/z (M+H) Calcd: 572.7, found: 572.2.

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