HCID 69004791, compound → HCID 69007001, compound

Participants

Reaction Conditions

Reaction Steps

[1-(4-Methoxy-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-acetic acid tert-butyl ester (0.19 mmol) is dissolved in 1.5 mL of TFA and heated to 100° C. for 3 hours. The mixture is cooled down to room temperature and concentrated. The residue is treated with NaOH (1N) (1 mL) and extracted with EtOAc (3×1 mL). The aqueous layer is then neutralized to pH=2 with HCl (1M) and extracted with EtOAc (3×2 mL). The organic layers resulted from this extraction is concentrated to provide the crude (2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-acetic acid. Yield: 72%.

Provenance & Evidence