Hydrochloric Acid → 3-Methoxyphenyl (2E)-3-[4-(tert-butyl)phenyl]prop-2-enoate

Participants

Reaction Steps

To a 100 mL round-bottomed flask equipped with magnetic stirring was added 4-tert-butyl-trans-cinnamic acid (500 mg, 2.45 mmol, EMKA-Chemie), CH2Cl2 (10 mL), and DMF (10 uL) under N2. The solution was treated dropwise with oxalyl chloride (4.0 mL, 8.0 mmol, 2.0 M in CH2Cl2, Aldrich) then stirred at 25° C. for 1 h. The reaction mixture was concentrated in vacuo and the residue treated with 3-methoxyphenol (269 uL, 2.45 mmol, Aldrich), THF (20 mL) and satd K2CO3 (15 mL). The reaction mixture was stirred at 25° C. overnight, then acidified to pH 4.5 with 1 N HCl. The mixture was extracted with EtOAc (2×30 mL), the combined organic extract was dried and concentrated in vacuo. Purification by silica gel chromatography (5:1 hexane:EtOAc) provided the title product as a white solid. MP 83° C. MS (ESI, pos. ion) m/z: 311 (M+1).

Provenance & Evidence