Hydroxide → HCID 9802766, compound

HRID 2105701Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:35])[CH:4]([CH2:9][C:10]12[CH2:17][CH2:16][C:13]([C:18]3[NH:26][C:25]4[C:24](=[O:27])[N:23]([CH2:28][CH2:29][CH3:30])[C:22](=[O:31])[N:21]([CH2:32][CH2:33][CH3:34])[C:20]=4[N:19]=3)([CH2:14][CH2:15]1)[CH2:12][CH2:11]2)C(OC)=O.[OH-]>>[CH3:1][O:2][C:3](=[O:35])[CH2:4][CH2:9][C:10]12[CH2:15][CH2:14][C:13]([C:18]3[NH:26][C:25]4[C:24](=[O:27])[N:23]([CH2:28][CH2:29][CH3:30])[C:22](=[O:31])[N:21]([CH2:32][CH2:33][CH3:34])[C:20]=4[N:19]=3)([CH2:12][CH2:11]1)[CH2:16][CH2:17]2

Participants

Reactant 2

HCID 961Hydroxide

HCID 67078756HCID 67078756, compound

Product 1

HCID 9802766HCID 9802766, compound

Procedure

Hydrolysis of 2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-ylmethyl]malonic acid dimethyl ester (XLI, Example 107) with hydroxide at elevated temperature gives the title compound.

Sources & evidence

ORD record: ord-8e493088f7f74cfbaa740accdacc422d
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579354B2

Reaction notes

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