a Farnesol → Farnesyl eicosapentaenoate

Participants

Reaction Conditions

Reaction Steps

There were dissolved, in 1 g of isooctane, 100 mg of farnesol and 750 mg of ethyl ester of eicosapentaenoic acid, followed by the addition of lipase in an amount of 1% relative to the total amount of the resulting solution and then stirring the mixture at 60° C. for 24 hours. After confirming whether the reaction system reached its equilibrium state or not by the GC technique, the reaction solution was diluted by the addition of hexane to the solution in an amount of 10 times the volume thereof, followed by the removal of the lipase from the reaction solution through filtration and then the removal of the hexane through distillation to thus give a crude reaction product. The crude product was purified by silica gel column chromatography to give 107 mg of farnesyl eicosapentaenoate.

Provenance & Evidence