反应详情

温度

60 °C

There were dissolved, in 1 g of isooctane, 100 mg of geranyl geraniol and 600 mg of ethyl ester of eicosapentaenoic acid, followed by the addition of lipase in an amount of 1% relative to the total amount of the resulting solution and then stirring the mixture at 60° C. for 24 hours. After confirming whether the reaction system reached its equilibrium state or not by the GC technique, the reaction solution was diluted by the addition of hexane to the solution in an amount of 10 times the volume thereof, followed by the removal of the lipase from the reaction solution through filtration and then the removal of the hexane through distillation to thus give a crude reaction product. The crude product was purified by silica gel column chromatography to give 102 mg of geranyl-geranyl eicosapentaenoate.

1. customfollowed by the removal of the lipase from the reaction solution through filtration
2. customthe removal of the hexane
3. distillationthrough distillation
4. customto thus give a crude
5. customreaction product
6. customThe crude product was purified by silica gel column chromatography