反应详情

Solution of 2-bromo-7-methylnaphthalene (10 g, 45 mmole) in ether (100 ml) was cooled to −0° C., and Ni(dppp)Cl2 and solution of PhLi (obtained from 1.3 g of Mg and 5.6 ml of PhBr in 55 ml of ether) were added subsequently. Reaction mixture was allowed to warm to room temperature, stirred for additional 4 h with heating, cooled room temperature, stirred for additional 16 h, and treated by water (100 ml). Organic layer was separated, water layer was extracted by ether (3×50 ml). Combined organic fraction was evaporated, giving practically pure solid product. The yield 9.23 g (94%).

1. customReaction mixture
2. temperaturewith heating
3. temperaturecooled room temperature
4. stirringstirred for additional 16 h
5. customOrganic layer was separated
6. extractionwater layer was extracted by ether (3×50 ml)
7. customCombined organic fraction was evaporated
8. customgiving practically pure solid product