HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → (r)-5-(3,5-Bis-trifluoromethyl-phenyl)-1-(3-fluoro-benzyl)-2-methyl-1h-pyrrole-3-carboxylic acid sec-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | 3-Fluorobenzylamine | HCID 66853 | — |
| Reactant | (R)-sec-butylamine | HCID 2724537 | — |
| Reactant | 3,5-Bis(trifluoromethyl)phenacyl bromide | HCID 2736170 | — |
| Product | (r)-5-(3,5-Bis-trifluoromethyl-phenyl)-1-(3-fluoro-benzyl)-2-methyl-1h-pyrrole-3-carboxylic acid sec-butylamide | HCID 58999076 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(3,5-bis-trifluoromethyl-phenyl)-2-bromo-ethanone as compound of formula S, 3-fluorobenzylamine as R3—(CH2)m—NH2 and (R)-sec-butylamine as R1R2NH, MS (ISP) 501.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579369B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-0d4a46104d274b8f8025e4f304d55b1e |
| Source note | uspto-grants-2009_08 |