Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,1,1-Trifluoro-2-iodoethane | HCID 67709 | — |
| Reactant | HCID 178492563 | HCID 178492563 | — |
| Product | HCID 58998957 | HCID 58998957 | — |
Reaction Steps
To 70 mg of 1-Cyclohexylmethyl-5-(4-hydroxy-2-methyl-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide (Example 111) in DMF was added 115 mg of potassium carbonate and 0.067 ml of 1,1,1-trifluoro-2-iodo-ethane. The reaction mixture was heated at 100° C. for 16 hours. The reaction mixture was then concentrated in vacuo and purified by column chromatography to give the title compound; MS (ISP) 491.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07579369B2 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-eaf6e463cf844de2b4d6f448146658c1 |
|---|
| Source note | uspto-grants-2009_08 |
|---|
