Methyl acetoacetate → HCID 58999100, compound

HRID 2105782Notes

Reaction equation

HRID 2105782 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[O:21][CH3:22])=O.[F:23][C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=1)[CH2:27][CH2:28][NH2:29].[F:33][C:34]([F:39])([F:38])[CH2:35][CH2:36][NH2:37]>>[F:33][C:34]([F:39])([F:38])[CH2:35][CH2:36][NH:37][C:3]([C:4]1[CH:10]=[C:11]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[O:21][CH3:22])[N:29]([CH2:28][CH2:27][C:26]2[CH:30]=[CH:31][CH:32]=[C:24]([F:23])[CH:25]=2)[C:5]=1[CH3:6])=[O:2]

Participants

5

Reactant 4

HCID 7757Methyl acetoacetateHCID 100013,3,3-TrifluoropropylamineHCID 709972-Bromo-2',5'-dimethoxyacetophenoneHCID 5339282-(3-Fluorophenyl)ethanamine

Product 1

HCID 58999100HCID 58999100, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2,5-dimethoxy-phenyl)-ethanone as compound of formula S, 3-fluoro-phenethylamine as R3—(CH2)m—NH2 and 3,3,3-trifluoro-N-propylamine as R1R2NH, MS (ISP) 479.2 (M+H)+.

Sources & evidence

ORD record
ord-b7b3cfcc8a2247b8be81b980c6786b5b
Source dataset
uspto-grants-2009_08
Patent number
US07579369B2

Reaction notes

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