Methyl acetoacetate → HCID 58998981, compound

HRID 2105785Notes

Reaction equation

HRID 2105785 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[O:21][CH3:22])=O.[Cl:23][C:24]1[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=1[CH2:26][CH2:27][NH2:28].[CH:33]1([NH2:39])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH:33]1([NH:39][C:3]([C:4]2[CH:10]=[C:11]([C:13]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=3[O:21][CH3:22])[N:28]([CH2:27][CH2:26][C:25]3[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=3[Cl:23])[C:5]=2[CH3:6])=[O:2])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1

Participants

5

Reactant 4

HCID 7757Methyl acetoacetateHCID 7965CyclohexylamineHCID 709972-Bromo-2',5'-dimethoxyacetophenoneHCID 831172-(2-Chlorophenyl)ethylamine

Product 1

HCID 58998981HCID 58998981, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2,5-dimethoxy-phenyl)-ethanone as compound of formula S, 2-chloro-phenethylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 481.3 (M+H)+.

Sources & evidence

ORD record
ord-b3b62c8a1e3c4b41a1e9d537f031e28d
Source dataset
uspto-grants-2009_08
Patent number
US07579369B2

Reaction notes

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