HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → 5-(3,5-Bis-trifluoromethyl-phenyl)-1-cyclopropylmethyl-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | 3,5-Bis(trifluoromethyl)phenacyl bromide | HCID 2736170 | — |
| Product | 5-(3,5-Bis-trifluoromethyl-phenyl)-1-cyclopropylmethyl-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 58998960 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(3,5-Bis-trifluoromethyl-phenyl)-2-bromoethanone as compound of formula S, cyclopropanemethylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 473.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579369B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-85ed0703f6f344bcabff08533f13910a |
| Source note | uspto-grants-2009_08 |