Methyl acetoacetate → HCID 58998975, compound

HRID 2105792Notes

Reaction equation

HRID 2105792 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[O:20][CH3:21])=O.[F:22][C:23]1[CH:31]=[CH:30][CH:29]=[CH:28][C:24]=1[CH2:25][CH2:26][NH2:27].[N:32]1([NH2:38])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[N:32]1([NH:38][C:3]([C:4]2[CH:10]=[C:11]([C:13]3[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=3[O:20][CH3:21])[N:27]([CH2:26][CH2:25][C:24]3[CH:28]=[CH:29][CH:30]=[CH:31][C:23]=3[F:22])[C:5]=2[CH3:6])=[O:2])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

5

Reactant 4

HCID 7757Methyl acetoacetateHCID 166581-AminopiperidineHCID 6433572-(2-Fluorophenyl)ethylamineHCID 27569852-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

Product 1

HCID 58998975HCID 58998975, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(5-fluoro-2-methoxy-phenyl)-ethanone as compound of formula S, 2-fluoro-phenethylamine as R3—(CH2)m—NH2 and 1-piperidinamine as R1R2NH, MS (ISP) 454.6 (M+H)+.

Sources & evidence

ORD record
ord-9d17c50a8bc14eacbf8a7072c70cbbc8
Source dataset
uspto-grants-2009_08
Patent number
US07579369B2

Reaction notes

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