Methyl acetoacetate → HCID 58999018, compound

HRID 2105799Notes

Reaction equation

HRID 2105799 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[O:20][CH3:21])=O.[CH:22]1([CH2:25][NH2:26])[CH2:24][CH2:23]1.[F:27][C:28]([F:33])([F:32])[CH2:29][CH2:30][NH2:31]>>[F:27][C:28]([F:33])([F:32])[CH2:29][CH2:30][NH:31][C:3]([C:4]1[CH:10]=[C:11]([C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=2[O:20][CH3:21])[N:26]([CH2:25][CH:22]2[CH2:24][CH2:23]2)[C:5]=1[CH3:6])=[O:2]

Participants

5

Reactant 4

HCID 7757Methyl acetoacetateHCID 100013,3,3-TrifluoropropylamineHCID 75646CyclopropanemethanamineHCID 27569852-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

Product 1

HCID 58999018HCID 58999018, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(5-fluoro-2-methoxy-phenyl)-ethanone as compound of formula S, cyclopropanemethylamine as R3—(CH2)m—NH2 and 3,3,3-trifluoro-N-propylamine as R1R2NH, MS (ISP) 399.4 (M+H)+.

Sources & evidence

ORD record
ord-4d1cc9daacf8443aa18fa5bc67a91d02
Source dataset
uspto-grants-2009_08
Patent number
US07579369B2

Reaction notes

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