HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → Cyclohexylmethyl-2-methyl-5-(3-methyl-pyrazin-2-yl)-1H-pyrrole-3-carboxylic acid cyclohexylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 2-Acetyl-3-methylpyrazine | HCID 32093 | — |
| Reactant | 2-Bromo-1-(3-methylpyrazin-2-yl)ethanone | HCID 23442580 | — |
| Product | Cyclohexylmethyl-2-methyl-5-(3-methyl-pyrazin-2-yl)-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 58998994 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using cyclohexylamine as R1R2NH, c-cyclohexyl-methylamine as R3—(CH2)m—NH2 and 2-bromo-1-(3-methyl-pyrazin-2-yl)-ethanone (available from 1-(3-methyl-pyrazin-2-yl)-ethanone [23787-80-6] following the procedure described by D. W. Robertson et. Al, J. Med. Chem., 29, 1986, 1577-1586); MS (ISP) 395.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579369B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-eb35e26b94854abe847d536c034ac115 |
| Source note | uspto-grants-2009_08 |