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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2105803Generated: October 27, 2026

Methyl acetoacetate → Cyclohexylmethyl-5-(2,5-difluoro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-amide

https://huagongshe.com/reaction/2105803

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl acetoacetateHCID 7757—
Reactant2-Bromo-1-(2,5-difluorophenyl)ethanoneHCID 2778264—
Reactantcis-2-Aminomethyl-1-cyclohexanolHCID 12483365—
ProductCyclohexylmethyl-5-(2,5-difluoro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-amideHCID 72485423—

Reaction Steps

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2,5-difluorophenyl)-ethanone as compound of formula S, c-cyclohexyl-methylamine as R3—(CH2)m—NH2 and cis-2-aminomethyl-1-cyclohexanol as R1R2NH, MS (ISP) 445.4 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07579369B2
Source datasetuspto-grants-2009_08
ORD IDord-2068bee03d4e40d8adb978e1c4d1c0d5
Source noteuspto-grants-2009_08