1-Bromo-4-(trifluoromethoxy)benzene → HCID 85981110, compound

HRID 2105814Notes

Reaction equation

HRID 2105814 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]([F:15])([F:14])[F:13])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[Br:16][C:17]1C=CC(OC(F)(F)F)=CC=1>>[Br:16][CH2:17][C:7]([C:6]1[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[O:11][C:12]([F:15])([F:14])[F:13])=[O:9]

Participants

3

Reactant 2

HCID 5210081-Bromo-4-(trifluoromethoxy)benzeneHCID 109460175-bromo-2-(trifluoromethoxy)benzoic Acid

Product 1

HCID 85981110HCID 85981110, compound

Procedure

The title compound was synthesized from 5-bromo-2-trifluoromethoxy-benzoic acid (prepared from 1-bromo-4-trifluoromethoxy-benzene by the orth-lithiation method according to Schlosser et al. Eur. J. Org. Chem. 2001, 21, 3991-3997) according to the general scheme 12.

Sources & evidence

ORD record
ord-5a338b64a6ae4c908b56588dd7a73155
Source dataset
uspto-grants-2009_08
Patent number
US07579369B2

Reaction notes

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