化工社化工社 化学情報印刷レポート · 研究参考用
Methyl acetoacetate → 5-(2-Fluoro-5-trifluoromethyl-phenyl)-1-((SR,2RS)-2-hydroxy-cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | 2-Fluoro-5-(trifluoromethyl)phenacyl bromide | HCID 2778784 | — |
| 反応物 | cis-2-Aminomethyl-1-cyclohexanol | HCID 12483365 | — |
| 生成物 | 5-(2-Fluoro-5-trifluoromethyl-phenyl)-1-((SR,2RS)-2-hydroxy-cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 10345085 | — |
反応手順
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-fluoro-5-trifluoromethyl-phenyl)-ethanone as compound of formula S, cis-2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 480.2 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07579369B2 |
| 出典データセット | uspto-grants-2009_08 |
| ORD ID | ord-24cf340e59b84d60a5398c2fa56f2c04 |
| 出典メモ | uspto-grants-2009_08 |