HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → 5-(2-Fluoro-5-trifluoromethyl-phenyl)-1-((SR,2RS)-2-hydroxy-cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | trans-2-Aminomethyl-1-cyclohexanol | HCID 2724658 | — |
| Reactant | 2-Fluoro-5-(trifluoromethyl)phenacyl bromide | HCID 2778784 | — |
| Product | 5-(2-Fluoro-5-trifluoromethyl-phenyl)-1-((SR,2RS)-2-hydroxy-cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 10345085 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-fluoro-5-trifluoromethyl-phenyl)-ethanone as compound of formula S, trans-2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 480.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579369B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-37476563fdac4323a11e7daadd5a61c4 |
| Source note | uspto-grants-2009_08 |