Chloroacetyl chloride → N-isopropyl-N-methyl-2-piperazin-1-yl-acetamide

HRID 2105860Notes

Reaction equation

C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.ClC[C:16](Cl)=[O:17].[CH:19]([NH:22][CH3:23])([CH3:21])[CH3:20]>>[CH:19]([N:22]([CH3:23])[C:16](=[O:17])[CH2:6][N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)([CH3:21])[CH3:20]

Participants

Reactant 3

HCID 6577Chloroacetyl chloride

HCID 78485N-Methylisopropylamine

HCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 28378703N-isopropyl-N-methyl-2-piperazin-1-yl-acetamide

Procedure

The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-isopropyl-N-methylamine in an analogous manner as described in example 21.

Sources & evidence

ORD record: ord-92d07b6577d44a809894874c9241df76
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579368B2

Reaction notes

Loading…