tert-Butyl piperazine-1-carboxylate → 1-(3-(Methylsulfonyl)propyl)piperazine

HRID 2105862Notes

Reaction equation

HRID 2105862 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[CH3:14][S:15]([CH2:18][CH2:19]COS(C)(=O)=O)(=[O:17])=[O:16]>>[CH3:14][S:15]([CH2:18][CH2:19][CH2:6][N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)(=[O:17])=[O:16]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 102627583-(Methylsulfonyl)propyl methanesulfonate

Product 1

HCID 498534781-(3-(Methylsulfonyl)propyl)piperazine

Procedure

The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine and methanesulfonic acid 3-methanesulfonyl-propyl ester (prepared according to Baerlocher, F. J. et al. Aust. J. Chem. 1999, 52, 167-172) in an analogous manner as described in example 21.

Sources & evidence

ORD record
ord-e89528e1153b4018ab2e50b6865cba63
Source dataset
uspto-grants-2009_08
Patent number
US07579368B2

Reaction notes

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