Chloroacetyl chloride → N-cyclopropyl-2-piperazin-1-ylacetamide

HRID 2105867Notes

Reaction equation

C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.ClC[C:16](Cl)=[O:17].[CH:19]1([NH2:22])[CH2:21][CH2:20]1>>[CH:19]1([NH:22][C:16](=[O:17])[CH2:6][N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH2:21][CH2:20]1

Participants

Reactant 3

HCID 6577Chloroacetyl chloride

HCID 69828Cyclopropylamine

HCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 4962600N-cyclopropyl-2-piperazin-1-ylacetamide

Procedure

The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetyl-chloride and cyclopropylamine in an analogous manner as described in example 21.

Sources & evidence

ORD record: ord-ec7ac8f16cd8423b8ac2437f6893b77b
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579368B2

Reaction notes

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