Methanesulfonyl chloride → Tert-butyl 4-(2-(methylsulfonamido)ethyl)piperazine-1-carboxylate
Reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[C:6]([O:10][C:11]([N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][NH2:21])[CH2:15][CH2:14]1)=[O:12])([CH3:9])([CH3:8])[CH3:7]>N1C=CC=CC=1>[C:6]([O:10][C:11]([N:13]1[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][NH:21][S:2]([CH3:1])(=[O:4])=[O:3])[CH2:17][CH2:18]1)=[O:12])([CH3:9])([CH3:8])[CH3:7]Participants
4
Procedure
Methanesulfonyl chloride (0.7 mL, 9.0 mmol) was added to a cooled solution of 4-(2-amino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (1.33 g, 5.8 mmol) in pyridine (25.0 mL). The reaction was stirred for 12 h and partitioned between partitioned between aqueous sodium bicarbonate and methylene chloride. The organic phase was washed with 1 M hydrochloric acid, aqueous sodium bicarbonate, and brine, dried over anhydrous magnesium sulfate and concentrated. Purification of the crude residue by chromatography over silica gel using 0-5% methanol in methylene chloride gave 4-(2-methanesulfonylamino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (0.70 g, 70%).
Workup
- custompartitioned
- custombetween partitioned between aqueous sodium bicarbonate and methylene chloride
- washThe organic phase was washed with 1 M hydrochloric acid, aqueous sodium bicarbonate, and brine
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated
- customPurification of the crude residue by chromatography over silica gel using 0-5% methanol in methylene chloride
Sources & evidence
- ORD record
- ord-ad0343fe0ce9426c8246db8743002a4f
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07579368B2
Reaction notes
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