反应详情

温度

120 °C

4,5-Bis-(4-chlorophenyl)-2-(2-ethoxy-4-iodophenyl)-4,5-dihydro-1H-imidazole (0.900 g, 1.68 mmol), tributyl-(1-ethoxyvinyl)tin (0.679 mL, 2.01 mmol) and tetrakis(triphenyl-phosphine)-palladium(0) (0.194 g, 0.168 mmol) were combined in toluene (10 mL) in a flame-dried Schlenk tube then heat at 120° C. for 20 h. After evaporation of volatiles, the residue was purified by flash column chromatography (silica gel, eluting with a gradient of 2-5% methanol in chloroform) to give 4,5-bis-(4-chlorophenyl)-2-[2-ethoxy-4-(1-ethoxyvinyl)phenyl]-4,5-dihydro-1H-imidazole as a faintly green foam (0.639 g, 79%). LC-MS: 481.4 [(M+H)+].

1. customAfter evaporation of volatiles
2. customthe residue was purified by flash column chromatography (silica gel
3. washeluting with a gradient of 2-5% methanol in chloroform)