HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-Hydroxyethyl)piperazin-2-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(2-hydroxyethyl)-3-oxopiperazine-1-carboxylate | HCID 68874055 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(2-Hydroxyethyl)piperazin-2-one hydrochloride | HCID 54595961 | 92.3% |
Reaction Steps
Hydrochloric acid (1.8 mL, 7.4 mmol, 4 M in 1,4-dioxane) was added to a solution of 4-tert-butyloxycarbonyl-1-(2-hydroxyethyl)-piperazin-2-one (0.45 g, 1.8 mmol) in 1,4-dioxane (5.0 mL). The mixture was stirred overnight and concentrated to give 1-(2-hydroxyethyl)-piperazin-2-one hydrochloride as an off-white solid (0.30 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579368B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-56e2f45b827542f0a465f8a6d17eed9d |
| Source note | uspto-grants-2009_08 |