Hydrochloric Acid → HCID 57810437, compound

Participants

Reaction Steps

Preparation according to Example 2: 4-[2-fluoro-3-(trifluoromethyl)phenyl]piperidin-4-ol (0.31 g, 1.18 mmol), potassium carbonate (0.3 g, 2.17 mmol), acetonitrile (20 ml), 1-bromo-2-methoxy ethane (0.11 ml, 1.3 mmol). Yield: (0.29 g, 76%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 159-160° C. MS m/z (relative intensity, 70 eV) 321 (M+, 3), 277 (13), 276 (bp), 258 (24) 191 (9).

Provenance & Evidence