Hydrochloric Acid → HCID 57810432, compound

Participants

Reaction Steps

Preparation according to Example 2: 4-[2-fluoro-3-(trifluoromethyl)phenyl]piperidin-4-ol (0.31 g, 1.18 mmol), acetonitrile (20 ml), potassium carbonate (0.3 g, 2.9 mmol), bromobutane (0.16 ml, 1.3 mmol). Yield: 0.26 g, 70%. The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 138° C. MS m/z (relative intensity, 70 eV) 319 (M+, 6), 277 (14), 276 (bp), 258 (23) 185 (9).

Provenance & Evidence